Polymyositis- Important Points to remember for PG Exams and USMLE

Polymyositis- Important Points to remember for PG Exams and USMLE

Polymyositis:

It is an inflammatory myopathy .Other types of inflammatory myopathies include Dermatomyositis and Inclusion body myositis.

Clinical Features:

  1. Symmetrical involvement of Proximal limb muscles and rare involvement of distal limb muscles.
  2. Involvement of pharangeal muscles can lead to dysphagia
  3. Neck flexor muscles involvement can lead to head drop and hence difficulty in holding the head.
  4. Respiratory muscles are involved in advanced stage.
  5. The most important point is the sparing of Extraocular muscles i.e. these muscles are not involved in inflammatory myopathies.
  6. There is no involvement of nerves and hence sensations remain normal.

 

Important point: No involvement of Skin in Polymyositis and no Cardiac involvement

Diagnosis of Polymyositis: Raised level of muscle enzymes, Characteristic EMG findings. However definite diagnosis has to be done by doing Muscle biopsy.

Treatment:

  1. Corticosteroids are the first line drugs
  2. Immunosuppressive therapy including Cyclosporine, Azathioprine, mycophenolate mofetil, monoclonal antibody CD 20
  3. Intravenous immunoglobulins and Rituximab

Other important Topics for NEET PG Exam include:

Bedaquiline and Delamanid Newer Drugs for MDR-TB for NEET PG Exam

Zollinger Ellison Syndrome Important Points for NEET PG and USMLE Exam

Macimorelin Growth Harmone Receptor agonist Question for NEET PG Exam

 Dabigatran Newer Oral Aticoagulant for NEET PG Exam 2018

 

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